A sugar-free vaccine
Vaccines that elicit broadly neutralizing antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) will be essential for curbing the ongoing coronavirus disease 2019 (COVID-19) pandemic. Here, Huang et al. evaluated the immunological impact of enzymatically removing glycan shields from the SARS-CoV-2 spike (S) protein. The authors found that immunizing hamsters or mice with S protein lacking glycan shields, termed SMG, elicited robust and broadly reactive immune responses. Vaccinated mice were protected from challenge with the alpha, gamma, and delta variants of concern. Antibodies isolated from vaccinated animals could also neutralize the omicron variant. Together, these data support further investigation into SMG as a candidate SARS-CoV-2 vaccine.
Protein in hyacinth beans can prevent coronavirus infections
民視英語新聞 Formosa TV English News | Hyacinth beans are a traditional Chinese medicine ingredient and they are also tasty in a curry. But Taiwanese researchers have found that they can also be useful in combating viral infections like COVID. The beans can be used to derive a protein called FRIL can prevent viruses from entering the nucleus of cells. Treating cells with the substance can decrease infection rates to under 5%...