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Structure of the heterotrimeric membrane protein complex FtsB-FtsL-FtsQ of the bacterial divisome


Hong Thuy Vy Nguyen, Xiaorui Chen, Claudia Parada, An-Chi Luo, Orion Shih, U-Ser Jeng, Chia-Ying Huang, Yu-Ling Shih* & Che Ma*

Nature Communications, 14, Article number: 1903 (2023)

Structural basis for a conserved neutralization epitope on the receptor-binding domain of SARS-CoV-2


Kuan-Ying A. Huang*, Xiaorui Chen, Arpita Mohapatra, Hong Thuy Vy Nguyen, Lisa Schimanski, Tiong Kit Tan, Pramila Rijal, Susan K. Vester, Rory A. Hills, Mark Howarth, Jennifer R. Keeffe, Alexander A. Cohen, Leesa M. Kakutani, Yi-Min Wu, Md Shahed-Al-Mahmud, Yu-Chi Chou, Pamela J. Bjorkman, Alain R. Townsend & Che Ma*

Nature Communications, 14, Article number: 311 (2023)

Structural basis of interleukin-17B receptor in complex with a neutralizing antibody for guiding humanization and affinity maturation


Lee WH, Chen X, Liu IJ, Lee JH, Hu CM, Wu HC, Wang SK, Lee WH, Ma C*

Cell Reports

Vaccination with SARS-CoV-2 spike protein lacking glycan shields elicits enhanced protective responses in animal models


Han-Yi Huang, Hsin-Yu Liao, Xiaorui Chen, Szu-Wen Wang, Cheng-Wei Cheng, Md. Shahed-Al-Mahmud, Yo-Min Liu, Arpita Mohapatra, Ting-Hua Chen, Jennifer M. Lo, Yi-Min Wu, Hsiu-Hua Ma, Yi-Hsuan Chang, Ho-Yang Tsai, Yu-Chi Chou, Yi-Ping Hsueh, Ching-Yen Tsai, Pau-Yi Huang, Sui-Yuan Chang, Tai-Ling Chao, Han-Chieh Kao, Ya-Min Tsai, Yen-Hui Chen, Chung-Yi Wu, Jia-Tsrong Jan, Ting-Jen Rachel Cheng, Kuo-I Lin*, Che Ma*, Chi-Huey Wong*

Science Translational Medicine, 14, eabm0899 (2022)

Identification of existing pharmaceuticals and herbal medicines as inhibitors of SARS-CoV-2 infection


Jan JT, Cheng TJ, Juang YP, Ma HH, Wu YT, Yang WB, Cheng CW, Chen X, Chou TH, Shie JJ, Cheng WC, Chein RJ, Mao SS, Liang PH*, Ma C*, Hung SC*, and WongCH*

Proceedings of the National Academy of Sciences of the United States of America, 118 (5), e2021579118

A Carbohydrate-Binding Protein from the Edible Lablab Beans Effectively Blocks the Infections of Influenza Viruses and SARS-CoV-2


Liu YM, Md. Shahed-Al-Mahmud, Chen X, Chen TH, Liao KS, Lo JM, Wu YM, Ho MC, Wu CY, Wong CH, Jan JT, Ma C*

Cell Reports, 32(6), 108016

Better influenza vaccines: an industry perspective


Chen JR, Liu YM, Tseng YC & Ma C*

Journal of Biomedical Science, 27(1), 33-44.

Egg-based influenza split virus vaccine with monoglycosylation induces cross-strain protection against influenza virus infections.


Tseng YC, Wu CY, Liu ML, Chen TH, Chiang WL, Yu YH, Jan JT, Lin KI, Wong CH*, and Ma C*

Proceedings of the National Academy of Sciences of the United States of America116(10): 4200-4205.

Structure-function analysis of neutralizing antibodies to H7N9 influenza from naturally infected humans.


Huang KA, Rijal P, Jiang H, Wang B, Schimanski L, Dong T, Liu YM, Chang P, Iqbal M, Wang MC, Chen Z, Song R, Huang CC, Yang JH, Qi J, Lin TY, Li A, Powell TJ, Jan JT, Ma C, Gao GF*, Shi Y*, Townsend AR*

Nature microbiology, 4(2): 306-315.

Targeting the Bacterial Transglycosylase: Antibiotic Development from a Structural Perspective.


Chen X, Wong CH, Ma C*

ACS Infectious Diseases, 5(9) 1493-1504.

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