Vaccination with SARS-CoV-2 spike protein lacking glycan shields elicits enhanced protective responses in animal models
Han-Yi Huang, Hsin-Yu Liao, Xiaorui Chen, Szu-Wen Wang, Cheng-Wei Cheng, Md. Shahed-Al-Mahmud, Yo-Min Liu, Arpita Mohapatra, Ting-Hua Chen, Jennifer M. Lo, Yi-Min Wu, Hsiu-Hua Ma, Yi-Hsuan Chang, Ho-Yang Tsai, Yu-Chi Chou, Yi-Ping Hsueh, Ching-Yen Tsai, Pau-Yi Huang, Sui-Yuan Chang, Tai-Ling Chao, Han-Chieh Kao, Ya-Min Tsai, Yen-Hui Chen, Chung-Yi Wu, Jia-Tsrong Jan, Ting-Jen Rachel Cheng, Kuo-I Lin*, Che Ma*, Chi-Huey Wong*
Science Translational Medicine, 14, eabm0899 (2022)
Identification of existing pharmaceuticals and herbal medicines as inhibitors of SARS-CoV-2 infection
Jan JT, Cheng TJ, Juang YP, Ma HH, Wu YT, Yang WB, Cheng CW, Chen X, Chou TH, Shie JJ, Cheng WC, Chein RJ, Mao SS, Liang PH*, Ma C*, Hung SC*, and WongCH*
Proceedings of the National Academy of Sciences of the United States of America, 118 (5), e2021579118
A Carbohydrate-Binding Protein from the Edible Lablab Beans Effectively Blocks the Infections of Influenza Viruses and SARS-CoV-2
Liu YM, Md. Shahed-Al-Mahmud, Chen X, Chen TH, Liao KS, Lo JM, Wu YM, Ho MC, Wu CY, Wong CH, Jan JT, Ma C*
Cell Reports, 32(6), 108016
Egg-based influenza split virus vaccine with monoglycosylation induces cross-strain protection against influenza virus infections.
Tseng YC, Wu CY, Liu ML, Chen TH, Chiang WL, Yu YH, Jan JT, Lin KI, Wong CH*, and Ma C*
Proceedings of the National Academy of Sciences of the United States of America116(10): 4200-4205.
Structure-function analysis of neutralizing antibodies to H7N9 influenza from naturally infected humans.
Huang KA, Rijal P, Jiang H, Wang B, Schimanski L, Dong T, Liu YM, Chang P, Iqbal M, Wang MC, Chen Z, Song R, Huang CC, Yang JH, Qi J, Lin TY, Li A, Powell TJ, Jan JT, Ma C, Gao GF*, Shi Y*, Townsend AR*
Nature Microbiology, 4(2): 306-315.
Crystal structure of a homogeneous IgG-Fc glycoform with the N-glycan designed to maximize the antibody dependent cellular cytotoxicity.
Chen CL, Hsu JC, Lin CW, Wang CH, Tsai MH, Wu CY, Wong CH*, Ma C*
ACS Chemical Biology, 12(5), 1335-1345.
A common glycan structure on immunoglobulin G for enhancement of effector functions.
Lin CW, Tsai MH, Li ST, Tsai TI, Chu KC, Liu YC, Lai MY, Wu CY, Tseng YC, Shivatare SS, Wang CH, Chao P, Wang SY, Shih HW, Zeng YF, You TH, Liao JY, Tu YC, Lin YS, Chuang HY, Chen CL, Tsai CS, Huang CC, Lin NH, Ma C, Wu CY*, Wong CH*
Proceedings of the National Academy of Sciences of the United States of America, 112(34), 10611-6.
Targeting IL-17B-IL-17RB signaling with an anti-IL-17RB antibody blocks pancreatic cancer metastasis by silencing multiple chemokines.
Wu HH, Hwang-Verslues WW, Lee WH, Huang CK, Wei PC, Chen CL, Shew JY, Lee EY, Jeng YM, Tien YW, Ma C, Lee WH*
Journal of Experimental Medicine, 212(3), 333-349.
Vaccination of monoglycosylated hemagglutinin induces cross-strain protection against influenza virus infections.
Chen JR, Yu YH, Tseng YC, Chiang WL, Chiang MF, Ko YA, Chiu YK, Ma HH, Wu CY, Jan JT, Lin KI*, Ma C*, Wong CH*
Proceedings of the National Academy of Sciences of the United States of America, 111(7), 2476-2481.
Autocrine/paracrine mechanism of interleukin-17B receptor promotes breast tumorigenesis through NF-kB-mediated antiapoptotic pathway.
Huang CK, Yang CY, Jeng YM, Chen CL, Wu HH, Chang YC, Ma C, Kuo WH, Chang KJ, Shew JY and Lee WH*
Oncogene, 33(23), 2968-77.
Crystal structure of Staphylococcus aureus transglycosylase in complex with a lipid II analog and elucidation of peptidoglycan synthesis mechanism.
Huang CY, Shih HW, Lin LY, Tien YW, Cheng TJR, Cheng WC, Wong CH*, and Ma C*
Proceedings of the National Academy of Sciences of the United States of America, 109(17), 6496-6501.